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    Transaction In Own Shares

    November 5, 2012

    Shire plc (the “Company”) (LSE: SHP, NASDAQ: SHPG), announces that in accordance with the authority granted by shareholders at the Company's Annual General Meeting on April 24, 2012 it purchased 66,101 of its ordinary shares of 5 pence each on November 5, 2012.  The highest and lowest price paid for these shares was 1767.00 pence per share and 1761.00 pence per share respectively.

    The purchased shares will be held as treasury shares. Following the above purchase, the Company holds 642,501 shares as treasury shares, and has 561,898,386 shares in issue (excluding treasury shares).

    For further information please contact:

    Investor Relations      

    Eric Rojas   
    erojas@shire.com
    +1 781 482 0999

    Sarah Elton-Farr   
    seltonfarr@shire.com
    +44 1256 894157

    Notes to editors

    Shire enables people with life-altering conditions to lead better lives.

    Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:

    • Behavioral Health and Gastro Intestinal conditions
    • Rare Diseases
    • Regenerative Medicine

    as well as other symptomatic conditions treated by specialist physicians.

    We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

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