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    PDMR Share Dealing

    December 17, 2012

    Shire plc (LSE: SHP, NASDAQ: SHPG) announces that Ms Tatjana May exercised today an option over 1,108 Shire plc ordinary shares of 5p each (“Shares”), granted under the Shire Sharesave Scheme, at an exercise price of £8.19 per Share.  Ms May retained the resulting Shares.  

    This notification is to satisfy the Company’s obligations under 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

    Tony Guthrie
    Deputy Company Secretary


    For further information please contact:

    Investor Relations       

    Eric Rojas   
    erojas@shire.com
    +1 781 482 0999

    Sarah Elton-Farr   
    seltonfarr@shire.com
    +44 1256 894157


    Notes to editors

    Shire enables people with life-altering conditions to lead better lives.

    Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:

    • Behavioral Health and Gastro Intestinal conditions
    • Rare Diseases
    • Regenerative Medicine

    as well as other symptomatic conditions treated by specialist physicians.

    We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

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