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    Half Yearly Report

    August 10, 2012

    In order to meet its obligations under the Disclosure Rules and Transparency Rules of the United Kingdom Financial Services Authority, Shire plc (“Shire” or the “Group”) (LSE: SHP, NASDAQ: SHPG) is publishing today its Half Yearly Report for the six months ended June 30, 2012.

    It should be noted that on August 1, 2012 Shire previously announced its results in respect of the same period.

    For further information please contact:

    Investor Relations       
    Eric Rojas erojas@shire.com +1 781 482 0999
    Sarah Elton-Farr   seltonfarr@shire.com +44 1256 894157
    Jessica Mann (Corporate) jmann@shire.com +44 1256 894 280


    Notes to editors

    Shire enables people with life-altering conditions to lead better lives.

    Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:

    • Behavioral health and Gastro Intestinal conditions
    • Rare Diseases
    • Regenerative Medicine

    as well as other symptomatic conditions treated by specialist physicians.

    We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

    For further information on Shire, please visit the Group’s website: www.shire.com.