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    Director/PDMR Share Dealings

    April 3, 2012

    Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company (the “Company”) announces that it was notified on April 2, 2012 that on March 30, 2012 the Ordinary Shares (“Shares”) and American Depository Shares (“ADSs”) in the Company set out below had been awarded under the Shire Executive Annual Incentive Plan (“EAIP”) to Persons Discharging Managerial Responsibility (“PDMRs”). The Shares and ADSs were acquired on March 30, 2012, at prices of £21.11 per Share and $97.3685 per ADS, respectively.

      Type of Security No of Shares/ADSs purchased
    Angus Russell (Chief Executive Officer) ADSs 2,907
    Graham Hetherington (Chief Financial Officer) Shares 4,552
    Michael Cola ADSs 1,205
    Barbara Deptula ADSs 846
    Sylvie Gregoire ADSs 1,410
    Tatjana May Shares 2,660
    Kevin Rakin ADSs 442

    The awards will not normally be released to participants for three years.  One ADS is equal to three Shares.

    In addition, the Company was notified on April 2, 2012 of the release, on the same day, of the following Shares and ADSs awarded in 2009 under the EAIP.

      Type of Security No of Shares/ADSs released No of Shares/ADSs sold to satisfy tax liabilities
    Angus Russell (Chief Executive Officer) Shares 37,814 12,264
    Graham Hetherington (Chief Financial Officer) Shares 9,007 4,659
    Michael Cola ADSs 6,374 2,447
    Barbara Deptula ADSs 4,902 2,029
    Sylvie Gregoire ADSs 5,631 2,236
    Tatjana May Shares 14,010 7,246

    On April 2, 2012 sufficient Shares and ADSs were sold to satisfy tax liabilities as set out above.  The Shares were sold at a price of £20.14 per Share and the ADSs were sold at an average price of $97.8240 per ADS.

    This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

    Tony Guthrie
    Deputy Company Secretary

     

    For further information please contact:

    Investor Relations    
    Eric Rojas erojas@shire.com +1 781 482 0999
    Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

     

    Notes to editors

    SHIRE PLC

    Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician.  Shire focuses its business on attention deficit hyperactivity disorder, human genetic therapies, gastrointestinal diseases and regenerative medicine as well as opportunities in other therapeutic areas to the extent they arise through acquisitions.  Shire’s in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights.  Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

    For further information on Shire, please visit the Company’s website: www.shire.com.

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