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    Block Listing Application

    November 12, 2012

    Shire plc (the “Company”) (LSE: SHP, NASDAQ: SHPG) hereby notifies the market that application has been made to the UK Listing Authority and the London Stock Exchange for a total of 110,000 ordinary shares of 5p each (“Shares”) to be admitted to the Official List. These Shares are being reserved under a block listing and will be issued to satisfy awards granted under the Shire Sharesave Scheme.

    These shares will rank pari passu in all respects with the existing issued Shares of the Company.

    For further information please contact:

    Investor Relations

    Eric Rojas (erojas@shire.com)

    +1 781 482 0999

     

    Sarah Elton-Farr (seltonfarr@shire.com)

    +44 1256 894157

    Notes to editors

    Shire enables people with life-altering conditions to lead better lives.

    Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:

    • Behavioral Health and Gastro Intestinal conditions
    • Rare Diseases
    • Regenerative Medicine

    as well as other symptomatic conditions treated by specialist physicians.

    We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

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